Structural Biology, Bioinformatics and Systems Approaches Researchers
Suvobrata Chakravarty
My lab focuses on understanding how proteins interact with other molecules (i.e., other proteins, DNA, RNA etc.) using bioinformatics, biophysical chemistry and structural biology to discover how natural germline and somatic mutations impact human protein function. In this research pursuit, we have developed: (a) experimental tools for rapid determination of affinity of protein–protein interactions, (b) algorithms for the study of weak molecular interactions, (c) analysis procedures for the study of specific protein interactions and (d) procedures for genome-scale analysis of mutations.
I seek to understand the structure and function of the nuclear envelope in health and disease and to uncovering the underlying mechanisms of nuclear envelopathies. In response to barriers in his research on the nuclear envelope, I established a method called BioID to screen for protein proximity and interactions in living cells, thus overcoming several limitations intrinsic to conventional approaches. Since it is uniquely capable of screening for protein associations in living cells, BioID is rapidly becoming an established method used by the scientific community.
